Product Name	IL17D
Chinese Name	白介素-17D抗体
Alias	Interleukin-17D; IL 17D; IL 27; IL17D; IL-17D; IL27; Interleukin 17D; Interleukin 27; Interleukin-17; pfam06083; IL17D_HUMAN.
literatures	Specific References  (2)     |     SL2612R has been referenced in 2 publications. [IF=5.714] Tianming Li. et al. IL-17D affects the chemokines and chemokine receptors of intestinal epithelial cells under hyperoxia. INT IMMUNOPHARMACOL. 2022 Dec;113:109386   PubMed:36461593 [IF=3.098] Xuying Liu. et al. Involvement of nuclear factor erythroid 2‑related factor 2 in neonatal intestinal interleukin‑17D expression in hyperoxia. Int J Mol Med. 2020 Oct;46(4):1423-1432  WB,IF,IHC ;  Rat.   PubMed:32945417
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-17D: 31-130/202
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008] Function: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Subcellular Location: Secreted. Tissue Specificity: Expressed preferentially in adipose, skeletal muscle and CNS. Similarity: Belongs to the IL-17 family. SWISS: Q8TAD2 Gene ID: 53342 Database links: Entrez Gene: 53342 Human Entrez Gene: 239114 Mouse Omim: 607587 Human SwissProt: Q8TAD2 Human Unigene: 655142 Human
Product Picture	Sample: Jurkat (Human) Cell Lysate at 40 ug Primary: Anti-IL17D (SL2612R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20 kD Observed band size: 25 kD Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (IL17D) Polyclonal Antibody, Unconjugated (SL2612R) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (IL17D) Polyclonal Antibody, Unconjugated (SL2612R) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.

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