Product Name	IL10RB
Chinese Name	白细胞介素-10受体β抗体
Alias	Cd210; CDw210b; CRF2 4; CRF2-4; CRFB4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Cytokine receptor family II member 4; D21S58; D21S66; I10R2_HUMAN; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; IL10R2; IL10RB; Interleukin 10 receptor beta; Interleukin-10 receptor subunit 2; Interleukin-10 receptor subunit beta.
literatures	Specific References  (3)     |     SL2602R has been referenced in 3 publications. [IF=4.86] Ohnuma et al. Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes. (2015) J.Immuno. 194:3697-712  FC/FACS,WB ;  Mouse.   PubMed:25786689 [IF=3.317] Wang, Jingru. et al. Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model. Bmc Pulm Med. 2021 Dec;21(1):1-10  IHC ;  Mouse.   PubMed:34836520 [IF=2.66] Lopušná, Katarína, et al. "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." Cytokine 83 (2016): 158-170.  WB ;  Mouse.   PubMed:27152708
Research Area	immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-10RB: 21-120/325 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Interleukin 10 binds specifically and with high affinity to cell surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. Subcellular Location: Membrane; Single-pass type I membrane Similarity: Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains. SWISS: Q08334 Gene ID: 3588 Database links: Entrez Gene: 3588 Human Entrez Gene: 16155 Mouse Entrez Gene: 304091 Rat Omim: 123889 Human SwissProt: Q08334 Human SwissProt: Q61190 Mouse Unigene: 654593 Human Unigene: 4154 Mouse
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Lung (Mouse) Lysate at 40 ug Lung (Rat) Lysate at 40 ug Primary: Anti-IL10RB (SL2602R) at 1/200 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD Sample: Lane 1: Spleen (Rat) Lysate at 40 ug Lane 2: Lung (Rat) Lysate at 40 ug Lane 3: Small intestine (Rat) Lysate at 40 ug Lane 4: Lymph node (Rat) Lysate at 40 ug Primary: Anti-IL10RB (SL2602R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kD Observed band size: 33 kD

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