Product Name	GCSF Receptor
Chinese Name	粒细胞-巨噬细胞集落刺激因子3受体抗体
Alias	GCSF Receptor; CD 114; CD114; CD114 antigen; Colony stimulating factor 3 receptor (granulocyte); Colony stimulating factor 3 receptor; CSF 3R; CSF3R; CSF3R_HUMAN; Csfgr; G CSF R; G-CSF receptor; G-CSF-R; G-CSFR; GCSFR; Granulocyte colony stimulating factor receptor; Granulocyte colony stimulating factor receptor precursor; Granulocyte colony-stimulating factor receptor.
literatures	Specific References  (5)     |     SL2574R has been referenced in 5 publications. [IF=4.671] Hong L et al. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2019 Nov 19. pii: mjz105.  WB ;  Mouse.   PubMed:31742349 [IF=4] Hong L et al. Protective effects of Human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020 Jun 11;12(5):372-385.  WB ;  Human.   PubMed:31742349 [IF=3.777] Jia-hui Che. et al. Macrophage Polarization in Placenta Accreta and Macrophage-trophoblast Interactions. AM J REPROD IMMUNOL. 2022 Aug;:  IHC ;  Human.   PubMed:36000792 [IF=1.78] Tajima, Shogo, et al. "Case Report Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly proliferating." Int J Clin Exp Pathol 7.10 (2014): 7034-7041.  IHC-P ;  Human.   PubMed:25400792 [IF=1.69] Zhang, Enji, et al. "Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain." Molecular Medicine Reports (2017).  WB, IHC-P ;  Rat, Human.   PubMed:28656207
Research Area	Cell biology  immunology  Developmental biology  Signal transduction  Stem cells  Growth factors and hormones  The cell membrane受体  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G-CSFR: 101-200/863 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by the GCSF Receptor gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, of which three are membrane-bound and the one secreted and soluble. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Function: Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Subunit: Homodimer. The dimeric receptor binds two CSF3 molecules. Subcellular Location: Isoform 2: Secreted (Probable). Cell membrane; Single-pass type I membrane protein. Tissue Specificity: One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta. DISEASE: Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:162830]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: Q99062 Gene ID: 1441 Database links: Entrez Gene: 1441 Human Entrez Gene: 12986 Mouse Omim: 138971 Human SwissProt: Q99062 Human SwissProt: P40223 Mouse Unigene: 524517 Human Unigene: 271701 Mouse
Product Picture	Sample: 293T Cell (Human) Lysate at 30 ug Primary: Anti- GCSF Receptor (SL2574R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 95kD Observed band size: 120kD

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