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Product Name FPR1 Chinese Name 甲酸基肽受体1抗体 Alias Formyl peptide receptor 1; fMet Leu Phe receptor; FMLP; FMLP Receptor; FPR 1; FPR; N formyl peptide chemoattractant receptor; N formyl peptide receptor; N formylpeptide chemoattractant receptor; fMet-Leu-Phe receptor; FMLPR; FPR; FPR receptor; FPR1; FPR1_HUMAN; N formylpeptide chemoattractant receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor. literatures Specific References (3) | SL2572R has been referenced in 3 publications.[IF=6.6] Ana Paula Girol. et al. Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis. Cells-Basel. 2021 Nov;10(11):3170 IHC ; Rat.[IF=4.26] Wang et al. Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells. (2016) Sci.Re. 6:25946 WB, IF(ICC) ; Rat.[IF=4.12] Franken et al. Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates. (2015) Sci.Rep. 5:12940 FC/FACS ; Mouse.Research Area Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FPR1: 51-150/350 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Function:
High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Neutrophils.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P21462
Gene ID:
2357
Database links:Entrez Gene: 2357 Human
Omim: 136537 Human
SwissProt: P21462 Human
Unigene: 753 Human
transcriptional regulatory factor(Transcriptin Regulators)
FPR1属于G protein-coupled receptor家族成员,参与细胞信号传导,激活MAPK通路,免疫应答。Product Picture Sample:
Lane 1: U87MG (Human) Cell Lysate at 30 ug
Lane 2: U251 (Human) Cell Lysate at 30 ug
Lane 3: U937 (Human) Cell Lysate at 30 ug
Lane 4: SW480 (Human) Cell Lysate at 30 ug
Primary: Anti-FPR1 (SL2572R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60 kD
Observed band size: 60 kD
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