Product Name	TFPI
Chinese Name	组织因子途径抑制剂抗体
Alias	Tissue factor pathway inhibitor; Tissue factor pathway inhibitor-1; convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; TFI; TFPI 1; TFPI1; TFPI1_HUMAN.
Research Area	Cardiovascular
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TFPI: 101-200/304
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Subcellular Location: Isoform Alpha: Secreted. Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Mostly in endothelial cells. Post-translational modifications: O-glycosylated. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. SWISS: P10646 Gene ID: 7035 Database links: Entrez Gene: 7035 Human Entrez Gene: 21788 Mouse Entrez Gene: 29436 Rat Omim: 152310 Human SwissProt: P10646 Human SwissProt: O54819 Mouse SwissProt: Q02445 Rat Unigene: 516578 Human Unigene: 124316 Mouse Unigene: 447013 Mouse Unigene: 15795 Rat 组织因子途径抑制因子(tissue factor pathway in hibitor, TFPI)是组织因子凝血途径的主要抑制因子， 组织因子途径抑制因子在诸如动脉粥样硬化，血管再狭窄，弥漫性血管内凝血DIC等方面，有一定的研究价值。
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Lung (Rat) Lysate at 40 ug Primary: Anti-TFPI (SL2535R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 52 kD

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