Product Name	CD151
Chinese Name	CD151抗体
Alias	CD151 antigen; CD151 molecule; GP27; Membrane glycoprotein SFA1; MER2; PETA3; Platelet endothelial tetraspan antigen 3; RAPH; SFA 1; SFA1; Tetraspanin24; TSPAN24; CD151_HUMAN; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD151.
literatures	Specific References  (1)     |     SL2524R has been referenced in 1 publications. [IF=5.793] Ceshu Gao. et al. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. J Neuroinflamm. 2021 Dec;18(1):1-16  WB ;  Human.   PubMed:34022890
Research Area	Tumour  immunology  The cell membrane受体  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	28kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD151: 101-200/253 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Subunit: Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. DISEASE: Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the tetraspanin (TM4SF) family. SWISS: P48509 Gene ID: 977 Database links: Entrez Gene: 977 Human Omim: 602243 Human SwissProt: P48509 Human Unigene: 654379 Human CD151蛋白是四跨膜超家族蛋白(transmembrane-4 superfamily，TM4SF)成员，参与调节细胞的形态和极性、促进细胞黏附和迁移，并在体外血管形成中发挥着重要作用，该蛋白与血管新生有关。
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-CD151 (SL2524R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kD Observed band size: 28 kD

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