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Product Name CD99 Chinese Name CD99抗体 Alias T-cell surface glycoprotein E; T cell surface glycoprotein E2 precursor; 12E7; Antigen identified by monoclonal 12E7 Y homolog; Antigen identified by monoclonal antibodies 12E7 F21 and O13; CD 99; CD99 antigen; CD99 molecule; CD99X; E2 antigen; Ewing Sarcoma; MIC 2; MIC 2X; MIC 2Y; MIC2; MIC2X; MIC2Y; Monoclonal antibody 12E7; MSK5X; Protein MIC2; Surface antigen MIC2. literatures Specific References (1) | SL2523R has been referenced in 1 publications.[IF=20.565] Aguayo-Mazzucato C et al. β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. (2017) Cell.Metab. 25:898-910.e5 IF ; Mouse.Research Area Tumour Cell biology immunology Cell Surface Molecule glycoprotein t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 16kDa Detection molecular weight 32 kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse CD99: 45-150/175 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.
Subunit:
Homodimer. Interacts with PILRB.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Natural killer cells.
Similarity:
Belongs to the CD99 family.
SWISS:
Q8VCN6
Gene ID:
673094
Database links:Entrez Gene: 4267 Human
Entrez Gene: 673094 Mouse
Omim: 313470 Human
SwissProt: P14209 Human
SwissProt: Q8VCN6 Mouse
Unigene: 653349 Human
Unigene: 423040 Mouse
CD99(P30/32MIC2)是一种Transmembrane protein,为MIC2基因产物。分布于lymphocyte、胸腺皮质细胞、卵巢的颗粒细胞、胰岛细胞和睾丸支持细胞。Product Picture
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