Product Name	ZNF217
Chinese Name	Zinc finger protein217抗体
Alias	zinc finger protein 217; ZABC 1; ZABC1; ZN 217; ZN217; ZNF 217; 4933431C08Rik; AW987152; Gm562; Zfp217; ZN217_HUMAN .
literatures	Specific References  (2)     |     SL2510R has been referenced in 2 publications. [IF=5.008] Cohen et al. The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value. (2015) Oncotarget. 6:41566-81  IHC ;  Human.   PubMed:26431164 [IF=2.766] Li et al. MiR-203 suppresses ZNF217 upregulation in colorectal cancer and its oncogenicity. (2015) PLoS.One. 10:e0116170  IHC ;  Human.   PubMed:25621839
Research Area	Tumour  immunology  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	115kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZNF217: 151-250/1061
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression. Function: Binds to the promoters of target genes and functions as epressor. Promotes cell proliferation and antagonizes cell death. romotes phosphorylation of AKT1 at 'Ser-473'. Subunit: Component of a histone deacetylase complex that contains DAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone eacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, DM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and TF2I. Interacts with CTBP1 and CTBP2. Subcellular Location: Nucleus (Probable). Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers. SWISS: O75362 Gene ID: 7764 Database links: Entrez Gene: 7764 Human Omim: 602967 Human SwissProt: O75362 Human Unigene: 155040 Human Unigene: 711564 Human

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