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Product Name AIMP2 Chinese Name AIMP2抗体 Alias Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aimp2; AA407136; AA407225; Aimp2(p38); JTV 1 protein; Jtv1; MGC30261; MGC36346; MGC36522; MGC37389; ARS interacting multi functional protein 2; Multisynthetase complex auxiliary component p38; P38; tRNA SYNTHETASE COFACTOR p38; PRO0992; Protein JTV 1; JTV-1; JTV1; P38; PRO0992; AIMP2_HUMAN. literatures Specific References (1) | SL2509R has been referenced in 1 publications.[IF=3.22] Du, Wei, et al. "Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after Inhaled Corticosteroid Withdrawal in COPD Rats." The American Journal of Chinese Medicine 44.05 (2016): 1027-1041. WB ; Rat.Research Area Cell biology immunology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Pig, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 36kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human AIMP2: 201-300/320 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail P38 is a probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. Mediates ubiquitination of FUBP1 and its degradation by the proteasome. P38 is also a cofactor of multi-ARS complex and also a substrate of parkin in neuronal cell.
Function:
Required for assembly and stability of the minoacyl-tRNA synthase complex. Mediates ubiquitination and egradation of FUBP1, a transcriptional activator of MYC, leading o MYC down-regulation which is required for aveolar type II cell ifferentiation. Blocks MDM2-mediated ubiquitination and egradation of p53/TP53. Functions as a proapoptotic factor.
Subunit:
Component of the aminoacyl-tRNA synthase complex which is omprised of a bifunctional glutamyl-prolyl-tRNA synthase, the onospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, rginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). nteracts in both its unphosphorylated and phosphorylated forms ith p53/TP53 (via N-terminus) in the nucleus following UV rradiation. Interacts (via N-terminus) with KARS and PARK2/parkin via first RING-type domain).
Subcellular Location:
Cytoplasm, cytosol (By similarity). Nucleus By similarity). Note=Following DNA damage, dissociates from the minoacyl-tRNA synthase complex and translocates from the cytoplasm o the nucleus (By similarity).
Post-translational modifications:
Phosphorylated on serine residues in response to UV rradiation (By similarity).
Ubiquitinated by PARK2, leading to its degradation by the roteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, llowing its accumulation which may contribute to neurodegeneration ssociated with Parkinson disease.
Similarity:
Contains 1 GST C-terminal domain.
SWISS:
Q13155
Gene ID:
7965
Database links:Entrez Gene: 7965 Human
Entrez Gene: 231872 Mouse
Omim: 600859 Human
SwissProt: Q13155 Human
SwissProt: Q8R010 Mouse
Unigene: 301613 Human
Unigene: 728827 Human
Unigene: 200499 Mouse
Unigene: 162097 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AIMP2) Polyclonal Antibody, Unconjugated (SL2509R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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