Product Name	MCT4/SLC16A3
Chinese Name	单羧酸转运蛋4抗体
Alias	Monocarboxylate transporter 4; Slc16a3; Mct3; Mct4; MCT-4; Monocarboxylate transporter 3; solute carrier family 16 member 3; SLC16A3; MOT4_HUMAN.
Research Area	Tumour  Cell biology  transcriptional regulatory factor  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MCT4/SLC16A3: 401-465/465 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008] Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in skeletal muscle. Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. SWISS: O15427 Gene ID: 9123 Database links: Entrez Gene: 9123 Human Entrez Gene: 80879 Mouse Entrez Gene: 80878 Rat Omim: 603877 Human SwissProt: O15427 Human SwissProt: P57787 Mouse SwissProt: O35910 Rat Unigene: 500761 Human Unigene: 28632 Mouse Unigene: 10826 Rat
Product Picture	Sample: Lane 1: Mouse Muscle tissue lysates Lane 2: Rat Muscle tissue lysates Primary: Anti-MCT4/SLC16A3 (SL24898R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 50 kD

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