Product Name	CD244
Chinese Name	CD244抗体
Alias	NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4 ; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4.
literatures	Specific References  (2)     |     SL2470R has been referenced in 2 publications. [IF=6.66] Peiffer, Daniel S., et al. "Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer." Cancer immunology research 4.1 (2016): 72-82.  IHC-P ;  Rat.   PubMed:26603620 [IF=4.047] Xu Xiaoyan. et al. A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection. PARASITE VECTOR. 2022 Dec;15(1):1-15  WB ;  Human.   PubMed:36153598
Research Area	Cell biology  immunology  Stem cells  Cell adhesion molecule  Cell Surface Molecule  Natural killer cells  lymphocyte  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD244: 151-250/370 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Function: Modulate other receptor-ligand interactions to enhance leukocyte activation. Subunit: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. Similarity: Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: Q9BZW8 Gene ID: 51744 Database links: Entrez Gene: 51744 Human Entrez Gene: 18106 Mouse Entrez Gene: 64025 Rat Omim: 605554 Human SwissProt: Q9BZW8 Human SwissProt: Q07763 Mouse SwissProt: Q9JLM2 Rat Unigene: 157872 Human Unigene: 2299 Mouse Unigene: 113760 Rat Unigene: 53994 Rat
Product Picture	Sample: Lane 1: Rat Thymus tissue lysates Lane 2: Rat Lymph node tissue lysates Lane 3: Human Serum Primary: Anti-CD244 (SL2470R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size:42 kD Observed band size:70 kD Cell: A549 (2% Paraformaldehyde fixed for 10 minutes). Concentration: primary antibody, 1:100;Secondary antibody,1: 50. Incubation: primary antibody ,1 hour;Secondary antibody,40 minutes; at Room temperature. Host/Blank: A549. Flow cytometric analysis of Rabbit Anti-CD244 antibody (SL2470R)(green) compared with control in the absence of primary antibody (blue) followed by A549. Secondary antibody: Goat Anti-rabbit IgG/FITC antibody (SL0295G-FITC)

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