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Product Name IGFBP5 Chinese Name 胰岛素样生长因子Binding protein5抗体 Alias IBP 5; IBP5; IGF binding protein 5; IGF BP5; Insulin Like Growth Factor Binding Protein 5; IBP5_HUMAN; Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5. Research Area Tumour immunology Signal transduction Growth factors and hormones Diabetes Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 30kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IGFBP5: 171-270/272 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.
Subcellular Location:
Secreted.
Tissue Specificity:
Osteosarcoma, and at lower levels in liver, kidney and brain.
Similarity:
Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.
SWISS:
P24593
Gene ID:
3488
Database links:Entrez Gene: 3488 Human
Entrez Gene: 16011 Mouse
Omim: 146734 Human
SwissProt: P24593 Human
SwissProt: Q07079 Mouse
Unigene: 607212 Human
Unigene: 405761 Mouse
Unigene: 1593 Rat
Growth factors and hormones( Growth Factor and Hormones)
IGFBP5胰岛素样生长因子Binding protein5(IGFBP-5)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGFBP-5与IGFs结合可以调节IGFs与IGF-I型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用。
有人认为:由于造骨细胞能表达与IGF-1受体截然不同的IGFBP-5受体,IGFBP-5本身也是一种生长因子,能够不依赖IGF-I独立作用来调节骨代谢。Product Picture Sample:
Lane 1: Kidney (Mouse) Tissue Lysate at 40 ug
Lane 2: Cerebrum (Mouse) Tissue Lysate at 40 ug
Lane 3: Hela (Human) Cell Lysate at 30 ug
Lane 4: HepG2 (Human) Cell Lysate at 30 ug
Lane 5: MCF-7 (Human) Cell Lysate at 30 ug
Primary:
Anti-IGFBP5 (SL24706R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 30 kD
Observed band size: 28 kD
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