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Product Name 5-HTR3 Chinese Name 5-羟色胺受体3抗体 Alias 5 HT 3; 5 HT3; 5 HT3A; HTR-3A; 5 HT3A receptor; 5 HT3R; 5 HT3RA; 5 hydroxytryptamine (serotonin) receptor 3A; 5 Hydroxytryptamine receptor 3; 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT 3; 5HT 3A; 5HT receptor; 5HT3 serotonin receptor; 5HT3A_HUMAN; 5HT3R; HTR 3; HTR3; Htr3a; Serotonin gated ion channel receptor; Serotonin receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor 3a; 5HT3A_HUMAN. Research Area Neurobiology Channel protein The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 53kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human 5-HTR3: 81-180/478 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
Subunit:
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in brain. Higher levels of expression are observed in the cerebellum, occipital cortex and frontal cortex.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P46098
Gene ID:
3359
Database links:Entrez Gene: 3359 Human
Entrez Gene: 15561 Mouse
Omim: 182139 Human
SwissProt: P46098 Human
SwissProt: P23979 Mouse
Unigene: 413899 Human
Unigene: 4831 Mouse
Unigene: 55109 Rat
Product Picture Sample:
Lane 1: Stomach (Mouse) Tissue Lysate at 40 ug
Lane 2: Spinal cord (Rat) TissueLysate at 40 ug
Lane 3: Stomach (Rat) Tissue Lysate at 40 ug
Lane 4: Small intestine (Rat) Tissue Lysate at 40 ug
Lane 5: BV2 (Mouse) Cell Lysate at 30 ug
Lane 6: U251 (Human) Cell Lysate at 30 ug
Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary: Anti-5-HTR3 (SL24701R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 50 kD
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