Product Name	CLEC7A
Chinese Name	β葡聚糖受体抗体
Alias	CLC7A_HUMAN; C-type lectin domain family 7 member A; BGR; Beta GR; CLECSF12; DECTIN1; Beta-glucan receptor; beta Glucan Receptor; C-type lectin superfamily member 12; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1; Dectin 1; Dectin1; CD369; UNQ539/PRO1082;
literatures	Specific References  (5)     |     SL2455R has been referenced in 5 publications. [IF=19.227] Iván Ballasch. et al. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. BRAIN BEHAV IMMUN. 2023 Mar;109:144  WB ;  Mouse.   PubMed:36702234 [IF=4.784] Cui H et al. A β-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFα gene expression. Int J Biol Macromol. 2020 Jan 23;149:801-808.  WB ;  Mouse.   PubMed:31982530 [IF=4.784] Zhan Q et al. Structural Characterization and Immunomodulatory Activity of a Novel Acid Polysaccharide Isolated from the Pulp of Rosa laevigata Michx Fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.  Other ;  Mouse.   PubMed:31730989 [IF=4.012] Wu J et al. Paeonol ameliorates murine alcohol liver disease via mycobiota‐mediated Dectin‐1/IL‐1β signaling pathway. J Leukoc Biol. 2020 Mar 4.  WB ;  mouse.   PubMed:32129526 [IF=1.16] Li et al. Expression of dectin-1 during fungus infection in human corneal epithelial cells. (2014) Int.J.Ophthalmol. 7:34-7  IHC ;  Human.   PubMed:24634860
Research Area	Cell biology  immunology  lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	28kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLEC7A: 41-140/247 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]. Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). Subunit: Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Tissue Specificity: Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp. Post-translational modifications: on tyrosine residues in response to glucan binding. Similarity: Contains 1 C-type lectin domain. SWISS: Q9BXN2 Gene ID: 64581 Database links: Entrez Gene: 64581 Human Entrez Gene: 56644 Mouse Entrez Gene: 502902 Rat Omim: 606264 Human SwissProt: Q9BXN2 Human SwissProt: Q6QLQ4 Mouse Unigene: 143929 Human Unigene: 239516 Mouse β-葡聚糖受体是一种非调理素依赖性受体,可在免疫反应早期,在清除衰老细胞和防御感染方面发挥重要作用,进而实现其抗Tumour、抗感染等生物学效应。
Product Picture	Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Lung tissue lysates Primary: Anti-beta Glucan Receptor (SL2455R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kDa Observed band size: 28,47 kDa Sample: Spleen (Mouse) Lysate at 40 ug Thymus (Mouse) Lysate at 40 ug Primary: Anti- beta Glucan Receptor (SL2455R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kD Observed band size: 28 kD Sample: Lung(Mouse) lysate at 30ug; Primary: Anti-beta Glucan Receptor (SL2455R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1:5000 dilution; Predicted band size: 28 kD Observed band size: 28 kD Blank control:RAW264.7. Primary Antibody (green line): Rabbit Anti-Iba1 antibody (SL2455R) Dilution: 1ug/Test; Secondary Antibody (white blue line) : Goat anti-Rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control（orange line）：Normal Rabbit IgG Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control:THP-1. Primary Antibody (green line): Rabbit Anti-beta Glucan Receptor antibody (SL2455R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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Totalgoods,subtotals:￥Checkout