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Product Name CCL19 Chinese Name 巨噬细胞炎性蛋白19抗体 Alias Macrophage Inflammatory Protein 3β; ;Macrophage Inflammatory Protein 3 beta; Beta chemokine exodus 3; C C chemokine ligand 19; CC chemokine ligand 19; CCL19; Chemokine (C C motif) ligand 19; Chemokine (CC motif) ligand 19; Chemokine CC Motif Ligand 19; CK beta 11; CKb11; EBI1 ligand chemokine; ELC; Exodus 3; MGC34433; MIP 3 beta; MIP3 beta; MIP3B; OTTHUMP00000000531; SCYA19; Small inducible cytokine A19; CCL19_MOUSE. literatures Specific References (3) | SL2454R has been referenced in 3 publications.[IF=4.873] Xinli Niu. et al. Naringenin attenuates experimental autoimmune encephalomyelitis by protecting the intact of blood-brain barrier and controlling inflammatory cell migration. J Nutr Biochem. 2021 Mar;89:108560 IF ; Mouse.[IF=2.23] Borrelli, G. M., et al. "Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes." Reproductive Sciences (2015): 1933719115592711. IHC-P ; Human.[IF=0] Borrelli, Giuliano. Investigation of invasion factors in deep-infiltrating endometriosis. Diss. Freie Universität Berlin, 2015. IHC-P ; Human.Research Area Cell biology immunology Natural killer cells Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 9.2kDa Cellular localization Extracellular matrix Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse CCL19: 26-108/108 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008]
Function:
Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Specifically binds to chemokine receptor CCR7.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
O70460
Gene ID:
24047
Database links:Entrez Gene: 6363 Human
Entrez Gene: 24047 Mouse
Omim: 602227 Human
SwissProt: Q99731 Human
SwissProt: O70460 Mouse
Unigene: 50002 Human
Unigene: 426373 Mouse
Unigene: 441169 Mouse
Unigene: 459263 Mouse
Unigene: 6660 Mouse
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