Product Name	CCL17
Chinese Name	胸腺活化调节Chemokine抗体
Alias	TARC; CCL17; SCYA17; ABCD-2; C-C motif chemokine 17; A152E53; CC Chemokine TARC; CCL17; Chemokine CC Motif Ligand 17; MGC138271; MGC138273; Small Inducible Cytokine A17; Small Inducible Cytokine A17 Precursor; Small Inducible Cytokine Subfamily A (Cys Cys); Small Inducible Cytokine Subfamily A (Cys Cys) Member 17; T Cell Directed CC Chemokine; Thymus and activation regulated chemokine; CCL17_HUMAN.
literatures	Specific References  (4)     |     SL2453R has been referenced in 4 publications. [IF=5.34] Dian-Dong Hou. et al. Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. PHYTOMEDICINE. 2022 Jul;102:154200  IHC ;  Mouse.   PubMed:35671605 [IF=4.51] Chen, Yi-Lien, and Bor-Luen Chiang. "Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma." Molecular Therapy—Nucleic Acids 5.5 (2016): e316.  IHC-P ;  Mouse.   PubMed:27138176 [IF=3.361] Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676.  IHC-P ;  Mouse.   PubMed:31181406 [IF=2.264] Zhiyu Zhang. et al. CCL17 blockade by CCL17mAb/GSK-J4 ameliorates hyperalgesia in a rat model of postoperative pain. BIOL PHARM BULL. 2023 Feb 15  IF ;  Rat.   PubMed:36792181
Research Area	transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCL17: 41-103/103
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. TARC displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. TARC binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Subcellular Location: Secreted. Tissue Specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine. Post-translational modifications: One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: Q92583 Gene ID: 6361 Database links: Entrez Gene: 6361 Human Entrez Gene: 20295 Mouse Entrez Gene: 117518 Rat Omim: 601520 Human SwissProt: Q92583 Human Unigene: 546294 Human Unigene: 41988 Mouse Unigene: 46679 Rat

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