Product Name	TRPC6
Chinese Name	瞬时受体电位离子Channel protein6抗体
Alias	MTRP6; Short transient receptor potential channel 6; si:rp71-1p14.9; Transient Receptor Potential Cation Channel Subfamily C Member 6; Transient receptor protein 6; TRP 6; TRP-6; TRP6; TRPC 6; TrpC6; TRPC6_HUMAN; TRRP6; bZ1P14.9; FLJ11098; FLJ14863; FSGS2.
literatures	Specific References  (3)     |     SL2393R has been referenced in 3 publications. [IF=7.419] Zheng-Hao Sun. et al. Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. BIOMED PHARMACOTHER. 2023 May;161:114480  WB ;  Human.   PubMed:37002575 [IF=2.205] Pritesh P Jain. et al. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. 2020 Nov 25  WB ;  Mouse.   PubMed:33282184 [IF=1.851] H Cheng et al. Effect of SKF-96365 on cardiomyocyte hypertrophy induced by angiotensin II. Molecular Medicine Reports 21.2 (2020): 806-814.  WB ;  Rat.   PubMed:doi:10.3892/mmr.2019.10877
Research Area	Cell biology  immunology  Neurobiology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=0.2μg/Test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	106kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TRPC6: 651-750/931 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq]. Subunit: Interacts with MX1 and RNF24. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. Contains 4 ANK repeats. SWISS: Q9Y210 Gene ID: 7225 Database links: Entrez Gene: 7225 Human Entrez Gene: 22068 Mouse Entrez Gene: 89823 Rat Omim: 603652 Human SwissProt: Q9Y210 Human SwissProt: Q61143 Mouse Unigene: 159003 Human Unigene: 325086 Mouse Unigene: 105986 Rat
Product Picture	blank control(blue): U937 cells (fixed with 4% paraformaldehyde) Isotype control(orange): Cell lines treated with rabbit IgG (SL0295P)instead of the primary antibody to confirm that primary antibody binding is specific. primary antibody(Green):Rabbit Anti-CD162 antibody(SL2301R),Concebtration: 0.2μg/10^6 cells Secondary only control(light blue): Both cell lines treated with Goat Anti-rabbit IgG/FITC antibody (SL0295G-FITC) to confirm no background signal produced from secondary antibody alone.

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