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Product Name B4GALT6 Chinese Name B4GALT6抗体 Alias Beta-1,4-Galactosyltransferase 6; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 6; UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 6; UDP-Gal:Glucosylceramide Beta-1,4-Galactosyltransferase; UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 6; Beta-1,4-GalTase 6; Beta4Gal-T6; B4Gal-T6; Beta4GalT-VI; B4GT6_HUMAN; Research Area Cell biology Synthesis and Degradation glycoprotein Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 45kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human B4GALT6 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Function:
Required for the biosynthesis of glycosphingolipids.
Subcellular Location:
Golgi apparatus
Tissue Specificity:
High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.
Similarity:
Belongs to the glycosyltransferase 7 family.
SWISS:
Q9UBX8
Gene ID:
9331
Database links:Entrez Gene: 9331 Human
Entrez Gene: 56386 Mouse
Omim: 604017 Human
SwissProt: Q9UBX8 Human
SwissProt: Q9WVK5 Mouse
Unigene: 591063 Human
Unigene: 393827 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (B4GALT6) Polyclonal Antibody, Unconjugated (SL23824R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (rat adrenal gland tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (B4GALT6) Polyclonal Antibody, Unconjugated (SL23824R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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