Product Name	MYL9
Chinese Name	肌球蛋白调节多肽9(平滑肌亚型)抗体
Alias	MYL9_HUMAN; Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; MLC2; MRLC1; MYRL2; Myosin light chain.
literatures	Specific References  (2)     |     SL2380R has been referenced in 2 publications. [IF=4.192] Jinwen Yuan. et al. Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways. J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX  WB ;  Human.   PubMed:33749262 [IF=0.786] Dong QQ et al. SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells. Food Sci Biotechnol. 2018 Mar 22;27(4):1165-1173.  WB ;  Human.   PubMed:30263847
Research Area	Cell biology  immunology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:200-1000 ELISA=1:500-5000 IHC-P=1:100-500 IHC-F=1:200-1000 IF=1:200-1000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MYL9: 2-100/172
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MYL9 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. MYL9 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for MYL9 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the MYL9 in conformational transitions of smooth muscle myosin. Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains. Tissue Specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells. Post-translational modifications: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity). Similarity: Contains 3 EF-hand domains. SWISS: P24844 Gene ID: 10398 Database links: Entrez Gene: 10398 Human Entrez Gene: 98932 Mouse Entrez Gene: 296313 Rat Omim: 609905 Human SwissProt: P24844 Human SwissProt: Q9CQ19 Mouse SwissProt: Q64122 Rat Unigene: 504687 Human Unigene: 271770 Mouse Unigene: 6870 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat heart tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MYL9) Polyclonal Antibody, Unconjugated (SL2380R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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