Product Name	HO-1
Chinese Name	血红素氧合酶 1/热休克蛋白32抗体
Alias	Heme oxygenase (decycling) 1; Heme oxygenase 1; Hemox; HMOX 1; Hmox; HMOX1; HO 1; HO; HO1; Hsp32; bK286B10; D8Wsu38e.
literatures	Specific References  (17)     |     SL23397R has been referenced in 17 publications. [IF=10.383] Wenjie Chen. et al. Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy. ACS APPL MATER INTER. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse.   PubMed:37249181 [IF=7.419] Jinyu Shi. et al. Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis. BIOMED PHARMACOTHER. 2022 Sep;153:113437  IHC ;  Rat.   PubMed:10.1016/j.biopha.2022.113437 [IF=7.129] Yuan-yuan Wei. et al. Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway. ECOTOX ENVIRON SAFE. 2023 Feb;251:114527  IHC ;  Mouse.   PubMed:36628874 [IF=6.953] Jinshan Wu. et al. Protection by Hosta ventricosa polysaccharides against oxidative damage induced by t-BHP in HepG2 cells via the JNK/Nrf2 pathway. Int J Biol Macromol. 2022 May;208:453  WB ;  Human.   PubMed:35339497 [IF=6.458] Yuxiang Wang. et al. Fe3O4@polydopamine nanoparticle-loaded human umbilical cord mesenchymal stem cells improve the cognitive function in Alzheimer's disease mice by promoting hippocampal neurogenesis. Nanomed-Nanotechnol. 2021 Dec;:102507  WB ;  Human.   PubMed:34883265 [IF=6.291] Xiao Wang. et al. Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis. Ecotox Environ Safe. 2022 Mar;233:113339  WB ;  Chicken.   PubMed:35219255 [IF=6.291] Qingyun Guan. et al. Monochromatic blue light not green light exposure is associated with continuous light-induced hepatic steatosis in high fat diet fed-mice via oxidative stress. ECOTOX ENVIRON SAFE. 2022 Jul;239:113625  WB,IHC ;  Mouse.   PubMed:35588616 [IF=6.291] Shaofeng Wu. et al. The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks. Ecotox Environ Safe. 2021 Dec;228:112965  WB ;  Duck.   PubMed:34775344 [IF=6.208] Elisabetta Profumo. et al. Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation. INT J MOL SCI. 2022 Jan;23(21):13009  IF ;  Human.   PubMed:36361795 [IF=5.682] Ya Yang. et al. Abnormal phenotype of Nrf2 is associated with poor prognosis through hypoxic/VEGF-A-Rap1b/VEGFR2 pathway in gastric cancer. AGING-US. 2022 Apr 15; 14(7): 3293–3312  IHC ;  Human.   PubMed:35417854 [IF=4.451] Fan Wan. et al. Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2/HO-1 pathway. J Funct Foods. 2021 Dec;87:104808  WB ;  Mouse.   PubMed:10.1016/j.jff.2021.104808 [IF=4.253] Mengru Li. et al. The leaves of Scutellaria baicalensis Georgi attenuate brain aging in D-galactose-induced rats via regulating glutamate metabolism and Nrf2 signaling pathway. EXP GERONTOL. 2022 Dec;170:111978  WB ;  Rat.   PubMed:36244586 [IF=4.155] Quanwei Li. et al. Toxicological mechanism of large amount of copper supplementation: Effects on endoplasmic reticulum stress and mitochondria-mediated apoptosis by Nrf2/HO-1 pathway-induced oxidative stress in the porcine myocardium. J Inorg Biochem. 2022 May;230:111750  WB ;  Pig.   PubMed:35151098 [IF=3.895] Li P et al. Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens. Toxins (Basel). 2020 Feb 25;12(3).  WB ;  chicken.   PubMed:32106596 [IF=3.419] Zhang, Tianya. et al. Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy. HORM-INT J ENDOCRINO. 2022 Oct;:1-11  IHC, WB ;  Rat.   PubMed:36289188 [IF=2.688] Zhihai Yu. et al. Two contradictory facades of N-acetylcysteine activity towards renal carcinoma cells. J TAIBAH UNIV SCI. 2022;16(1):423-431  WB ;  Human.   PubMed:10.1080/16583655.2022.2070365 [IF=2.323] Li M et al. Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intestines of Diquat-Challenged Piglets. Animals (Basel) . 2020 Apr 7;10(4):631.  WB ;  piglet.   PubMed:32272553
Research Area	Tumour  Cardiovascular  immunology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse HO-1: 201-289/289
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The hemeoxygenase-1 calls that the hemoglobin oxidizes to synthesize the enzyme again-1( hemeoxygenase-1, HO-1) is the catalyst enzyme that a kind of hemoglobin declines the solution, under the NADPH and the cell dye P-450 revivification enzymes and the member oxygen functions, the catalyst HO-1 hemoglobin declines the solution as the courage green vegetable, CO and irons, the former revivification has the very strong anti- to oxidize the ability after become the red vegetable of courage , the latter is a kind of important letter to make the member. Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Subcellular Location: Microsome. Endoplasmic reticulum. Tissue Specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). DISEASE: Defects in HMOX1 are the cause of heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]. A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. Similarity: Belongs to the heme oxygenase family. SWISS: P09601 Gene ID: 3162 Database links: Entrez Gene: 442987 Dog Entrez Gene: 3162 Human Entrez Gene: 15368 Mouse Entrez Gene: 24451 Rat Omim: 141250 Human SwissProt: Q5E9F2 Cow SwissProt: P09601 Human SwissProt: P14901 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HO-1) Polyclonal Antibody, Unconjugated (SL23397R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HO-1) Polyclonal Antibody, Unconjugated (SL23397R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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