Product Name	Glutaredoxin 1
Chinese Name	谷氧还蛋白/巯基转移酶抗体
Alias	Glrx; Glrx1; GLRX1_HUMAN; Glutaredoxin; Glutaredoxin-1; Glutaredoxin1; Grx 1; Grx; Grx1; Thioltransferase 1; Thioltransferase; Thioltransferase-1; Thioltransferase1; TTase; TTase 1; TTase-1; TTase1.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Glutaredoxin 1: 21-80/106
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]. Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Subcellular Location: Cytoplasm. Similarity: Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain. SWISS: P35754 Gene ID: 2745 Database links: Entrez Gene: 515416 Cow Entrez Gene: 2745 Human Entrez Gene: 93692 Mouse Entrez Gene: 397463 Pig Entrez Gene: 64045 Rat Omim: 600443 Human SwissProt: P10575 Cow SwissProt: P35754 Human SwissProt: Q9QUH0 Mouse SwissProt: P12309 Pig SwissProt: P12864 Rabbit SwissProt: Q9ESH6 Rat Unigene: 28988 Human Unigene: 712696 Human Unigene: 25844 Mouse Unigene: 1484 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Glutaredoxin 1) Polyclonal Antibody, Unconjugated (SL23373R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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