Product Name	B7-1/CD80
Chinese Name	刺激分子B7-1蛋白抗体
Alias	Activation B7-1 antigen; B lymphocyte activation antigen B7; B7; B7-1; B7-1 antigen; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 antigen; CD80 molecule; CD80_MOUSE; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80.
Research Area	Tumour  immunology  Stem cells  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-1000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse B7-1/CD80: 1-100/306 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines. Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. Subcellular Location: Membrane. Tissue Specificity: Expressed on activated B-cells, macrophages and dendritic cells. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q00609 Gene ID: 12519 Database links: Entrez Gene: 941 Human Entrez Gene: 12519 Mouse Omim: 112203 Human SwissProt: P33681 Human SwissProt: Q00609 Mouse Unigene: 838 Human Unigene: 89474 Mouse
Product Picture	Sample: Lymph node (Mouse) Lysate at 40 ug Primary: Anti-CD80 (SL23296R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 60 kD Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti-CD80 (SL23296R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 60 kD Sample: Spleen (Mouse) Lysate at 40 ug SP2/0 (Mouse) CellLysate at 30 ug Primary: Anti-B7-1/CD80 (SL23296R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 60 kD Sample: Lane 1: Thymus (Mouse) Lysate at 40 ug Lane 2: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 3: SP2/0 (Mouse) Cell Lysate at 30 ug Lane 4: Thymus (Rat) Lysate at 40 ug Lane 5: Raji (Human) Cell Lysate at 30 ug Lane 6: K562 (Human) Cell Lysate at 30 ug Primary: Anti-B7-1/CD80 (SL23296R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60-65 kD Observed band size: 60 kD Sample: Lane 1: Spleen (Mouse) Lysate at 40 ug Lane 2: Lymph node (Mouse) Lysate at 40 ug Lane 3: Thymus (Mouse) Lysate at 40 ug Lane 4: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 5: Sp2/0 (Mouse) Cell Lysate at 30 ug Primary: Anti-B7-1/CD80 (SL23296R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60-65 kD Observed band size: 62 kD

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