Product Name	Cathepsin L (light chain)
Chinese Name	组织蛋白酶L抗体
Alias	Cathepsin L light chain; CathepsinL; CATL; CTSL; CTSL protein; DKFZp686A18159; FLJ31037; Major excreted protein; MEP; cath-L; CL; CATL1_MOUSE; CathepsinL1; Cathepsin L1,Cathepsin-L1; CTSL 1; CTSL-1,CTS L1,CTS-L1.
Research Area	Kinases and Phosphatases  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	5/37kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Cathepsin L (light chain): 251-334/334
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. Function: Important for the overall degradation of proteins in lysosomes. Subunit: Dimer of a heavy and a light chain linked by disulfide bonds. Subcellular Location: Lysosome. Similarity: Belongs to the peptidase C1 family. SWISS: P07711 Gene ID: 13039 Database links: Entrez Gene: 1514 Human Entrez Gene: 13039 Mouse Entrez Gene: 25697 Rat Omim: 116880 Human SwissProt: P07711 Human SwissProt: P06797 Mouse SwissProt: P07154 Rat Unigene: 726015 Human Unigene: 930 Mouse Unigene: 1294 Rat Synthesis and Degradation（Synthesis and Degradation） 组织蛋白酶L(cathepsin L CL)属于木瓜蛋白酶家族中的半胱氨酸蛋白水解酶，以酶原的形式贮存于溶酶体中. 参与许多特殊的生理过程，如激素原的激活、抗原呈递、组织器官的发育等。 在病理状态下，因各种原因所致的细胞损伤(如病原微生物、炎症因子、氧化应激等)可降解细胞成分或细胞间质基质成分，包括层粘素、IV型胶原纤维及纤维连接素等，与人类许多疾病如Tumour的浸润与转移、关节炎、骨质疏松、阿尔茨海姆病、多发性硬化症及其他慢性炎症性疾病有关.
Product Picture	Sample: Skin (Rat) Lysate at 40 ug Primary: Anti- Cathepsin L (light chain) (SL23161R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 5/37 kD Observed band size: 47 kD

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