Product Name	SLC10A2
Chinese Name	顶膜钠依赖性胆盐转运体蛋白抗体
Alias	ASBT; Apical sodium dependent bile acid transporter; Apical sodium- dependent bile acid transporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na+ bile acid cotransporter; Na+ dependent ileal bile acid transporter; NTCP2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family); Solute carrier family 10 member 2.
literatures	Specific References  (1)     |     SL23146R has been referenced in 1 publications. [IF=5.656] Sundaram S et al. Mechanism of Dyslipidemia in Obesity—Unique Regulation of Ileal Villus Cell Brush Border Membrane Sodium–Bile Acid Cotransport. Cells. 2019 Oct 3;8(10). pii: E1197.  WB ;  Human.   PubMed:31623375
Research Area	Tumour  immunology  Signal transduction  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASBT/SLC10A2: 131-230/348 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR. Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Subunit: Monomer and homodimer. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Primary bile acid malabsorption (PBAM) [MIM:613291]: An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269|PubMed:9109432}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. SWISS: Q12908 Gene ID: 6555 Database links: Entrez Gene: 6555 Human Entrez Gene: 20494 Mouse Entrez Gene: 29500 Rat Omim: 601295 Human SwissProt: Q12908 Human SwissProt: P70172 Mouse SwissProt: Q62633 Rat Unigene: 194783 Human Unigene: 3500 Mouse Unigene: 85891 Rat
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-SLC10A2 (SL23146R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 38 kD Observed band size: 43 kD

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