TEL: +86 571 56623320 EMAIL: [email protected]
Product Name CRMP4 Chinese Name 脑衰蛋白反应调节蛋白4抗体 Alias Unc 33 like phosphoprotein; Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; DPYSL3; DRP 3; DRP3; LCRMP; TUC4; Ulip 1; ULIP; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein. Research Area Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CRMP4: 88-135/570 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system.
Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity).
Subcellular Location:
Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Post-translational modifications:
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
SWISS:
Q14195
Gene ID:
1809
Database links:Entrez Gene: 1809 Human
Entrez Gene: 22240 Mouse
Omim: 601168 Human
SwissProt: Q14195 Human
SwissProt: Q62188 Mouse
Unigene: 519659 Human
Unigene: 428551 Mouse
Unigene: 8180 Mouse
Unigene: 93365 Rat
Scan Wechat Qrcode