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Product Name Ki-67, Alexa Flour 750 conjugated Chinese Name AF750标记的Ki67蛋白抗体 Alias Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_MOUSE. Research Area Tumour Cell biology Neurobiology Cyclin Cell differentiation Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, ) Applications IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 358kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse Ki-67: 2701-2800/2938 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
Function:
Thought to be required for maintaining cell proliferation.
Subcellular Location:
Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.
Similarity:
Contains 1 FHA domain.
SWISS:
P46013
Gene ID:
17345
Database links:Entrez Gene: 4288 Human
Entrez Gene: 17345 Mouse
Omim: 176741 Human
SwissProt: P46013 Human
SwissProt: Q91VE6 Mouse
Unigene: 689823 Human
Unigene: 80976 Human
Unigene: 4078 Mouse
Unigene: 233802 Rat
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