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Product Name Netrin-G1 Chinese Name 轴突生长诱向因子G1/神经突起生长导向因子G1抗体 Alias Axon guidance molecule; KIAA0976; Laminet 1; LMNT1; Netrin G1f; Netrin-G1; Ntng1; NTNG1_HUMAN; YLSR571. Research Area Neurobiology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 54kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Netrin-G1: 301-400/539 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015].
Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Subunit:
Interacts with NGL1.
Subcellular Location:
Cell membrane. Lipid-anchor, GPI-anchor, Extracellular side.
Tissue Specificity:
Highly expressed in the thalamus, with very low expression, if any, in other tissues.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.
SWISS:
Q9Y2I2
Gene ID:
22854
Database links:
Entrez Gene: 100714441 Guinea pig
Entrez Gene: 100060362 Horse
Entrez Gene: 22854 Human
Entrez Gene: 80883 Mouse
Entrez Gene: 100341879 Rabbit
Omim: 608818 Human
SwissProt: Q9Y2I2 Human
SwissProt: Q8R4G0 Mouse
Unigene: 657434 Human
Unigene: 732535 Human
Unigene: 39262 Mouse
Unigene: 162628 Rat
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