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Product Name phospholipasae C Chinese Name 产气荚膜梭菌(魏氏梭菌)磷脂酶C抗体 Alias PLC. literatures Specific References (2) | SL2273R has been referenced in 2 publications.[IF=4.16] Vidal, Jorge E., Joshua R. Shak, and Adrian Canizalez-Roman. "The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build C. perfringens biofilms." Infection and Immunity (2015): IAI-00240. other ;[IF=3.26] Vidal et al. The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms. (2015) Infect.Immun. 83:2430-42 IF ; C. perfringens strains.Research Area immunology Bacteria and viruses Immunogen Species Rabbit Clonality Polyclonal Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Form Liquid Concentration 1mg/ml immunogen Recombinded phospholipasae C full length protein: Recombinded phospholipasae C full length protein Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail A型产气荚膜梭菌病,又称魏氏梭菌性肠炎,是由A型产气英膜梭菌产生的外毒素引起的肠毒血症,产气荚膜梭菌广泛分布于自然界及人和动物消化道内 ,能引起人气性坏疽、食物中毒和多种动物的坏死性肠炎及肠毒血症等 ,产气荚膜梭菌是近年来我国家畜猝死症的主要病原。产气荚膜梭菌至少能产生15种外毒素及侵袭性酶类 ,具有较强的致病力是以腹泻为特征的的一种急性致死性传染病,其发病率、死亡率均高, 对畜牧业的危害极大,造成巨大的经济损失。
在各种毒素和酶中,以α毒素最为重要,α毒素是一种卵磷脂酶,能分解卵磷脂,人和动物的The cell membrane是磷脂和蛋白质的复合物,可被卵磷脂酶所破坏,故α毒素能损伤多种细胞的The cell membrane,引起溶血、组织坏死,vascular endothelial cell损伤,使血管通透性增高,造成水肿。
A型产气荚膜梭菌也是引起人的食物中毒和气肿疽的主要病原体,亦可引起动物的坏死性肠炎和肠毒血症,产气荚膜梭菌是继沙门氏菌、葡萄球菌后引起食物中毒的又一重要的病原菌。由于它存在广泛,因而传播也比较容易。其中部分A型产气荚膜梭菌还产生一种在生物医学上具有重要意义的毒素,即肠毒素(CPE),该毒素致病性很强,并可引起人的食物中毒,CPE阳性A型产气荚膜梭菌引起的食物中毒的病例,仅次于沙门氏菌和葡萄球菌引起的食物中毒病例,约占食物中毒病例总数的4-10%.
产气荚膜梭菌分为A、B、C、D、E、F六个毒素型。其中A、C、F对人致病,但A型是毒性最强、最常见的一种,为常见的致病菌。A 引起气性坏疽和胃肠炎型食物中毒;C型能引起坏死性肠炎。
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