TEL: +86 571 56623320 EMAIL: [email protected]
Product Name GLIPR1 Chinese Name 脑胶质瘤发病机制相关蛋白1抗体 Alias ALKN2972; GLIPR1-like protein 1; MGC26856; PRO7434; UNQ2972/PRO7434; GLIPR; RTVP1; GliPR 1; Protein RTVP-1; Glioma pathogenesis-related protein 1; GLIP1_HUMAN. Research Area Tumour Cell biology immunology Developmental biology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Applications IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 27kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse GLIPR1: 11-110/255 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Subcellular Location:
Single-pass membrane protein.
Tissue Specificity:
According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.
Similarity:
Belongs to the CRISP family.
SWISS:
Q9CWG1
Gene ID:
73690
Database links:Entrez Gene: 11010 Human
Omim: 602692 Human
SwissProt: P48060 Human
Unigene: 205558 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GLIPR1) Polyclonal Antibody, Unconjugated (SL22736R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Scan Wechat Qrcode