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Product Name CTGF Chinese Name 结缔组织生长因子抗体 Alias CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; CTGF; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN. literatures Specific References (2) | SL22360R has been referenced in 2 publications.[IF=6.691] Zhao, Boyuan. et al. Suspension state and shear stress enhance breast tumor cells EMT through YAP by microRNA-29b. 2021 Oct 07 WB ; Human.[IF=2.606] Lei Zhang. et al. Autologous bone marrow-derived mesenchymal stem cells for interstitial fibrosis and tubular atrophy: a pilot study. Renal Failure. 2021;43(1):1266-1275 IHC ; human.Research Area Cardiovascular immunology Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Chicken, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 36kDa Cellular localization Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CTGF: 281-349/349 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].
Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Subunit:
Monomer.
Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted.
Tissue Specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Similarity:
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.
SWISS:
P29279
Gene ID:
1490
Database links:Entrez Gene: 1490 Human
Omim: 121009 Human
SwissProt: P29279 Human
SwissProt: P29268 Mouse
Unigene: 410037 Human
Unigene: 390287 Mouse
Growth factors and hormones( Growth Factor and Hormones)
结缔组织生长因子(CTGF)是调节细胞增生、分化和Extracellular matrix形成的重要效应分子,可调节机体有关组织、细胞生长并与纤维化发生密切相关的一种因子,因而在肌体的各类创伤修复过程中具有重要的生理学意义。Product Picture Sample:
Lane 1: Huvec (Human) Cell Lysate at 30 ug
Lane 2: Hela (Human) Cell Lysate at 30 ug
Lane 3: U2os (Human) Cell Lysate at 30 ug
Primary:
Anti-CTGF (SL22360R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38/35 kD
Observed band size: 38 kD
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