Product Name	Phospho-TFEB(Ser142)
Chinese Name	磷酸化Tlymphocytetranscriptional regulatory factorTFEB抗体
Alias	TFEB(Phospho-Ser142); TFEB(Phospho-S142); TFEB(Phospho Ser142); p-TFEB(Ser142); Alpha TFEB; AlphaTFEB; bHLHe35; T cell transcription factor EB; T-cell transcription factor EB; TCFEB; Transcription factor EB; TFEB_HUMAN.
literatures	Specific References  (2)     |     SL22337R has been referenced in 2 publications. [IF=6.59] Dan Zhang. et al. Fagopyrum dibotrys extract alleviates hepatic steatosis and insulin resistance, and alters autophagy and gut microbiota diversity in mouse models of high-fat diet-induced non-alcoholic fatty liver disease. FRONT NUTR. 2022; 9: 993501  WB ;  Mouse.   PubMed:36451739 [IF=3.412] Hao Yu. et al. Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis. Front Vet Sci. 2022; 9: 816064  WB ;  Cow(Calve).   PubMed:35211541
Research Area	Cell biology  immunology  transcriptional regulatory factor  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human TFEB around the phosphorylation site of Ser142: PN(p-S)PM
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer. Function: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Subunit: Homodimer and heterodimer; with TFE3 or MITF. Subcellular Location: Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus. Post-translational modifications: Sumoylated; does not affect dimerization with MITF. Similarity: Belongs to the MiT/TFE family. Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P19484 Gene ID: 7942 Database links: Entrez Gene: 7942 Human Entrez Gene: 510032 Cow Entrez Gene: 609046 Dog Entrez Gene: 21425 Mouse Entrez Gene: 100157940 Pig Entrez Gene: 316214 Rat Omim: 600744 Human SwissProt: P19484 Human SwissProt: Q9R210 Mouse Unigene: 485360 Human Unigene: 715310 Human Unigene: 2305 Mouse Unigene: 22098 Rat
Product Picture	Sample: Pancreas (Mouse) Lysate at 40 ug Primary: Anti- Phospho-TFEB(Ser142) (SL22337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD Sample: Lymph node(Mouse) Lysate at 40 ug Primary: Anti- Phospho-TFEB(Ser142) (SL22337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD

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