Product Name	FOXM1
Chinese Name	叉头蛋白M1抗体
Alias	FKH L16; FKHL 16; FKHL16; Forkhead box M1; Forkhead box protein M1; Forkhead drosophila homolog like 16; Forkhead Drosophila like 16; Forkhead like 16; Forkhead related protein FKHL16; FOX M1; FOXM 1; FOXM 1c; FOXM1B; FOXM1c; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH 11; HFH11; HNF 3; HNF 3/fork head homolog 11; HNF 3/forkhead homolog 11; HNF3; Human putative M phase phosphoprotein 2; INS 1; INS1; M phase phosphoprotein 2; MPHOSPH 2; MPHOSPH2; MPM 2; MPM 2 reactive phosphoprotein 2; MPM2 reactive phosphoprotein 2; MPP 2; MPP2; PIG 29; PIG29; Transcription factor Trident; Trident; WIN; Winged helix factor from INS 1 cells; FOXM1_HUMAN.
literatures	Specific References  (1)     |     SL21487R has been referenced in 1 publications. [IF=6.922] Yiguan Qian. et al. Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma. J Inflamm Res. 2022; 15: 1099–1116  WB ;  Human.   PubMed:35210814
Research Area	Tumour  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	84kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FOXM1 : 221-320/763
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Forkhead Box (Fox) proteins are an extensive family of transcription factors that share homology in the winged helix DNA-binding domain and the members of which play essential roles in a diverse range of developmental processes as well as cellular proliferation, differentiation, and longevity. The Fox factors are especially important in the establishment of the body axis and the development of tissues from all three germ layers. FOXM1 is also overexpressed in many human cancers and has a role in tumorigenesis. Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Subcellular Location: Nucleus. Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. Post-translational modifications: Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: Q08050 Gene ID: 2305 Database links: Entrez Gene: 2305 Human Entrez Gene: 14235 Mouse Entrez Gene: 58921 Rat Omim: 602341 Human SwissProt: Q08050 Human SwissProt: O08696 Mouse SwissProt: P97691 Rat Unigene: 239 Human Unigene: 42148 Mouse Unigene: 10665 Rat FOXM1(Forkhead box M1)是Forkhead转录因子家族中的成员，在很多Tumour组织中都有不同的表达。
Product Picture	Sample: Lane 1: Mouse Thymus tissue lysates Lane 2: Mouse Testis tissue lysates Lane 3: Rat Testis tissue lysates Lane 4: Human U-2 OS cell lysates Lane 5: Human A431 cell lysates Primary: Anti-FOXM1 (SL21487R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kDa Observed band size: 125 kDa

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