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Product Name CHRM1/M-AChR M1 Chinese Name 毒蕈碱型乙酰胆碱受体M1抗体 Alias muscarinic acetylcholine receptor; M-AChR M1; Muscarinic Acetylcholine Receptor 1;cholinergic receptor, muscarinic 1; Chrm1; Chrm-1; M1; M1R; Muscarinic Acetylcholine receptor M1; Cholinergic receptor muscarinic 1; CHRM 1; CHRM1; HM 1; HM1; M1; M1 muscarinic cholinergic receptor; MGC30125; Muscarinic acetylcholine receptor M1; Acetylcholine receptor(M1). Research Area Cell biology The cell membrane受体 G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 51kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CHRM1/M-AChR M1: 281-380/460 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008].
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subunit:
Interacts with GPRASP2.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
SWISS:
P11229
Gene ID:
1128
Database links:
1128Entrez Gene: 1128 HumanEntrez Gene: 12669 Mouse
Omim: 118510 Human
SwissProt: P11229 Human
SwissProt: P12657 Mouse
AChR M1 毒蕈碱型乙酰胆碱受体M1,属于G protein-coupled receptor家族成员,主要分布于中枢神经系统和周围神经系统,乙酰胆碱与受体结合后诱导其功能:抑制酰苷酸环化酶、降解磷酸肌醇、膜钾离子通道开放.Product Picture Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebral cortex (Mouse) Lysate at 40 ug
Primary: Anti-CHRM1’M-AChR M1 (SL21484R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
Sample:
MCF-7 (Human) Cell Lysate at 30 ug
Cerebellum (Mouse) Lysate at 40 ug
Cerebrum (Mouse) Lysate at 40 ug
Large intestine (Mouse) Lysate at 40 ug
Primary: Anti-CHRM1’M-AChR M1 (SL21484R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
Sample:
MCF-7 (Human) Cell Lysate at 30 ug
Cerebellum (Mouse) Lysate at 40 ug
Cerebrum (Mouse) Lysate at 40 ug
Large intestine (Mouse) Lysate at 40 ug
Primary: Anti-CHRM1’M-AChR M1 (SL21484R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
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