Product Name	CALCRL
Chinese Name	降钙素基因相关肽1型受体抗体
Alias	CGRPR; CRLR; calcitonin receptor like precursor; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; CGRP type 1 receptor; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; Calcitonin Receptor Like Receptor; CGRP type 1 receptor; CALRL_HUMAN.
Research Area	Cell biology  immunology  Neurobiology  Signal transduction  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CALCRL: 351-450/461 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries. Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subunit: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Predominantly expressed in the lung and heart. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: Q16602 Gene ID: 10203 Database links: Entrez Gene: 10203 Human Entrez Gene: 54598 Mouse Entrez Gene: 397172 Pig Entrez Gene: 25029 Rat Entrez Gene: 527140 Cow Omim: 114190 Human SwissProt: Q16602 Human SwissProt: Q9R1W5 Mouse SwissProt: Q8WN93 Pig SwissProt: Q63118 Rat Unigene: 470882 Human Unigene: 11202 Rat
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-CALCRL (SL21475R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti- CALCRL (SL21475R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD

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