Product Name	IL17A
Chinese Name	白介素-17抗体
Alias	Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN.
literatures	Specific References  (7)     |     SL2140R has been referenced in 7 publications. [IF=4.481] Haghighi Javid Asal. et al. IL-17A immune pattern across genetic acantholytic and blistering disorders. CLIN EXP DERMATOL. 2023 Jan;:  IHC ;  Human.   PubMed:36632755 [IF=3.33] Niu, Yinghua, et al. "The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease." BMC immunology 12.1 (2011): 47.  IHC-P ;  Human.   PubMed:21851644 [IF=2.868] Mangino G et al. Interleukin‐17A affects extracellular vesicles release and cargo in human keratinocytes. Exp Dermatol. 2019 Sep;28(9):1066-1073.  WB ;  Human.   PubMed:31373041 [IF=1.96] Kou, Wei, et al. "Transforming growth factor-??1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment."Inflammation Research (2013): 1-7.2  ELISA ;  Human.   PubMed:23178794 [IF=1.65] Ghazi, H. F., N. A. Mohammed, and R. J. Hussein. "Tissue IL-17A expression associated with inflammatory lesions and ATG16L1 T300A allele in Crohn’s disease." International Journal of Advanced Research 3.1 (2015): 33-40.  IHC-P ;  Human.   PubMed:notpostedyet [IF=1.48] Tang, Wei‑Jing, et al. "Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma." Oncology Letters.  IHC-P ;  Human.   PubMed:28693282 [IF=1.39] Tang et al. Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma. (2017) Oncol.Lett. 14:561-568  IHC-P ;  Human.   PubMed:28693206
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-17: 35-130/155
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020] Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Restricted to a subset of activated T-cells. Post-translational modifications: Found both in glycosylated and nonglycosylated forms. Similarity: Belongs to the IL-17 family. SWISS: Q16552 Gene ID: 3605 Database links: Entrez Gene: 3605 Human Entrez Gene: 16171 Mouse Entrez Gene: 301289 Rat Omim: 603149 Human SwissProt: Q16552 Human SwissProt: Q62386 Mouse SwissProt: Q61453 Rat Unigene: 41724 Human 白细胞介素17（IL-17A）是一种来源于活化Tlymphocyte的cell factor,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性cell factor和造血cell factor参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。 人IL-17A与人IL-17F的同源性为40%，人与小鼠的IL-17F同源性近80%。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。
Product Picture	Sample: Lane 1: Rat Lymph node tissue lysates Lane 2: Mouse Lymph node tissue lysates Lane 3: Rat Thymus tissue lysates Primary: Anti-IL17A (SL2140R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 15 kD Observed band size: 22 kD

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