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Product Name PAF1 Chinese Name RNA聚合酶II相关因子PAF1抗体 Alias F23149 1; FLJ11123; hPAF1; PAF 1; PAF1; Paf1 RNA polymerase II associated factor homolog; PAF1_HUMAN; Pancreatic differentiation protein 2; PD 2; PD2; PD2 protein; RNA polymerase II associated factor homolog; RNA polymerase II-associated factor 1 homolog. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 60kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PAF1: 251-350/531 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Function:
The mammalian PAF1 complex is a multifunctional complex. The PAF1 complex interacts with RNA polymerase II and may be involved in both initiation and elongation, and in histone methylation and RNA processing. Has oncogenic activity in vivo and in vitro.
Subcellular Location:
Nucleus. Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Similarity:
Belongs to the PAF1 family.
SWISS:
Q8N7H5
Gene ID:
54623
Database links:Entrez Gene: 54623 Human
Entrez Gene: 54624 Mouse
Entrez Gene: 446278 Xenopus laevis
Omim: 610506 Human
SwissProt: Q8N7H5 Human
SwissProt: Q8K2T8 Mouse
SwissProt: A2BD83 Xenopus laevis
Unigene: 466714 Human
Unigene: 7916 Mouse
Unigene: 161558 Rat
Unigene: 29705 Xenopus laevis
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