Product Name	LY6E
Chinese Name	Tlymphocyte激活蛋白6E抗体
Alias	Ly-6E ; LY6E_HUMAN ; LY6E_MOUSE ; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein ; RIG-E ; RIGE; SCA2; TSA1; 9804; SCA-2 ; Stem cell antigen 2 ; Thymic shared antigen 1 ; TSA-1 .
Research Area	Cell biology  immunology  Stem cells  lymphocyte  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse LY6E: 31-80/136
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021] Function: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). Tissue Specificity: Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes. Similarity: Contains 1 UPAR/Ly6 domain. SWISS: Q64253 Gene ID: 17069 Database links: Entrez Gene: 17069 Mouse SwissProt: Q64253 Mouse Unigene: 788 Mouse Unigene: 3321 Rat
Product Picture	Sample:Thymus (Mouse)Lysate at 40 ug Primary: Anti-LY6E(SL20838R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 14kD Observed band size: 14kD

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