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Product Name PTPRN2 Chinese Name 胰岛细胞自身抗原相关蛋白PTPRN2抗体 Alias IA 2beta; IA2beta; IAR; IAR/receptor like protein tyrosine phosphatase; ICAAR; Islet cell autoantigen related protein; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase receptor pi; Protein tyrosine phosphatase, receptor type, N polypeptide 2; PTPR2_HUMAN; Ptprn2; PTPRP; R PTP N2; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; Tyrosine phosphatase IA 2 beta. Research Area Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 109kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse PTPRN2: 521-620/1015 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Function:
Implicated in development of nervous system and pancreatic endocrine cells.
Subcellular Location:
Membrane.
Tissue Specificity:
Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.
Post-translational modifications:
Appears to undergo multiple proteolytic cleavage at consecutive basic residues. Similarity : Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.
SWISS:
P80560
Gene ID:
19276
Database links:Entrez Gene: 5799 Human
Entrez Gene: 19276 Mouse
Omim: 601698 Human
SwissProt: Q92932 Human
SwissProt: P80560 Mouse
Unigene: 490789 Human
Unigene: 206054 Mouse
Unigene: 11044 Rat
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