Product Name	CACNB1
Chinese Name	钙通道电压依赖性β1蛋白抗体
Alias	CAB1; CACNLB1; Calcium channel voltage dependent beta 1 subunit; Voltage dependent L type calcium channel beta 1 subunit; CACB1_HUMAN.
Research Area	Cell biology  immunology  Signal transduction  transcriptional regulatory factor  Channel protein  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 Flow-Cyt=3μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CACNB1: 1-100/568
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 (By similarity). Subcellular Location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. Similarity: Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. SWISS: Q02641 Gene ID: 782 Database links: Entrez Gene: 327703 Cow Entrez Gene: 782 Human Entrez Gene: 12295 Mouse Entrez Gene: 50688 Rat Omim: 114207 Human SwissProt: Q9MZL7 Cow SwissProt: Q02641 Human SwissProt: Q8R3Z5 Mouse SwissProt: P19517 Rabbit SwissProt: P54283 Rat Unigene: 635 Human Unigene: 41252 Mouse Unigene: 9417 Rat
Product Picture	Blank control (blue line): MCF 7 (fixed with 70% methanol (Overnight at 4℃) and then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody (green line): Rabbit Anti-CACNB1 antibody (SL20579R),Dilution: 3μg /10^5 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC<,Dilution: 1μg /test.

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