Product Name	Semaphorin 5A
Chinese Name	Transmembrane proteinSEMA5A抗体
Alias	Semaphorin 5A; Semaphorin-5A; Semaphorin5A; SEMA5A; SEMAF; Semaphorin F; SEM5A_HUMAN.
Research Area	Cell biology  Neurobiology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	118kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Semaphorin 5A: 671-770/1074 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene. Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Subunit: Binds PLXNB3. Subcellular Location: Membrane; single-pass type I membrane protein Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 7 TSP type-1 domains. SWISS: Q13591 Gene ID: 9037 Database links: Entrez Gene: 9037 Human Entrez Gene: 20356 Mouse Omim: 609297 Human SwissProt: Q13591 Human SwissProt: Q62217 Mouse
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-Semaphorin 5A (SL20430R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 118 kD Observed band size: 118 kD

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