Product Name	Neogenin
Chinese Name	神经细胞粘附蛋白NGN抗体
Alias	NGN; Neo1; Neo 1; Neogenin; NEO1_HUMAN.
Research Area	Cell biology  Neurobiology  Cell adhesion molecule  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	156kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Neogenin: 1001-1100/1461 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cell surface protein that is a memberof the immunoglobulin superfamily. The encoded protein consists offour N-terminal immunoglobulin-like domains, six fibronectin typeIII domains, a transmembrane domain and a C-terminal internaldomain that shares homology with the tumor suppressor candidategene DCC. This protein may be involved in cell growth anddifferentiation and in cell-cell adhesion. Defects in this gene areassociated with cell proliferation in certain cancers. Alternatesplicing results in multiple transcript variants. [provided byRefSeq, Feb 2010]. Function: Neogenin is one of several netrin-binding proteins. Neogenin functions as an Repulsive Guidance Molecule (RGM) receptor; RGM is implicated in axonal guidance and neural tube closure. Subunit: Interacts with RGMA. Interacts with MYO10 Subcellular Location: Cell membrane; Single-pass type I membraneprotein. Tissue Specificity: Widely expressed and also in cancer celllines. Similarity: Belongs to the immunoglobulin superfamily. DCC family. Contains 6 fibronectin type-III domains. Contains 4 Ig-like C2-type (immunoglobulin-like)domains. SWISS: Q92859 Gene ID: 4756 Database links: Entrez Gene: 4756 Human Entrez Gene: 18007 Mouse Entrez Gene: 81735 Rat Omim: 601907 Human SwissProt: Q92859 Human SwissProt: P97798 Mouse SwissProt: P97603 Rat Unigene: 388613 Human Unigene: 42249 Mouse Unigene: 10667 Rat

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