Product Name	TGF beta 2
Chinese Name	转化生长因子β2（TGFβ2）抗体
Alias	Transforming growth factor beta-2 proprotein; TGFB2; TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor factor; Glioblastoma-derived T-cell suppressor factor; GTSF; MGC116892; Polyergin; TGF beta2; TGF-beta-2; TGF-beta2; TGFB 2; TGFB2_HUMAN; Transforming growth factor beta 2; Transforming growth factor beta-2.
literatures	Specific References  (4)     |     SL20412R has been referenced in 4 publications. [IF=8.702] Xiao, Jiangwei. et al. IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties. CELL MOL BIOL LETT. 2023 Dec;28(1):1-24  WB ;  Mouse.   PubMed:36849929 [IF=6.543] Zhong Li. et al. The TBX1/miR-193a-3p/TGF-β2 Axis Mediates CHD by Promoting Ferroptosis. Oxid Med Cell Longev. 2022;2022:5130546  WB ;  Human.   PubMed:35035663 [IF=5.191] Chao Ye. et al. Naringin in the repair of knee cartilage injury via the TGF-β/ALK5/Smad2/3 signal transduction pathway combined with an acellular dermal matrix. J Orthop Transl. 2021 Aug;:  IHC ;  Rabbit.   PubMed:10.1016/j.jot.2021.06.004 [IF=2.379] Weiwei Liu. et al. CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia. 2020 Aug 25  WB ;  Mouse.   PubMed:32904464
Research Area	Tumour  Cell biology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TGF beta 2: 351-414/414
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF Alpha. It is now realized that TGF beta s mediate many cell-cell interactions that occur during embryonic development. Three TGF beta s have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Subunit: Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Subcellular Location: Secreted. Similarity: Belongs to the TGF-beta family. SWISS: P61812 Gene ID: 7042 Database links: Entrez Gene: 7042 Human Entrez Gene: 21808 Mouse Omim: 190220 Human SwissProt: P21214 Cow SwissProt: P61812 Human SwissProt: P27090 Mouse Unigene: 133379 Human Unigene: 18213 Mouse
Product Picture	Sample: MDA-MB-231 (human)cell Lysate at 40 ug Primary: Anti- TGF beta2 (SL20412R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 48 kD Sample: Placenta (Mouse)Lysate at 40 ug Bladder (Mouse)Lysate at 40 ug Primary: Anti-TGF beta 2(SL20412R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 50kD Observed band size: 50kD Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Rat Heart tissue lysates Primary: Anti-TGF beta 2 (SL20412R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 50 kDa

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