Product Name	TGF-beta 3
Chinese Name	转移生长因子β3抗体（TGFβ3）
Alias	Transforming growth factor beta-3 proprotein; TGFB3; ARVD; FLJ16571; MGC105479; MGC118722; TGF beta 3; TGF beta3; TGF-beta-3; TGF-beta 3; TGFB 3; Transforming growth factor beta-3; TGFB3_HUMAN.
Research Area	Signal transduction  Stem cells  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30/47kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TGF-beta 3: 321-412/412
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The TGFBeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factors Beta(TGFBeta) 1,2 and 3; placental transforming growth factor (PTGFBeta);growth /differentiation factors (GDFs); mullerian inhibiting substance (MIS);bone morphogenic proteins (BMPs);glial cell line-derived neurotrophic factor (GDNF);inhibins or activins (Alpha,Beta-A, Beta-B and Beta-C),Lefty and Nodal. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. Function: Involved in embryogenesis and cell differentiation. Subunit: Homodimer; disulfide-linked. Interacts with ASPN. Subcellular Location: Secreted. DISEASE: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Similarity: Belongs to the TGF-beta family. SWISS: P10600 Gene ID: 7043 Database links: Entrez Gene: 7043 Human Entrez Gene: 21809 Mouse Entrez Gene: 25717 Rat Omim: 190230 Human SwissProt: P10600 Human SwissProt: P17125 Mouse SwissProt: Q07258 Rat Unigene: 592317 Human Unigene: 3992 Mouse Unigene: 7018 Rat Growth factors and hormones（ Growth Factor and Hormones） TGF是一种多效生长因子,对epithelial cells增值有潜在抑制作用,可抑制Tumour生长，用于许多恶性Tumour如:胃癌、肺癌、膀胱癌、肾癌、前列腺癌、结肠癌等多种恶性Tumour的研究。分子量：47kDa。此抗体是TGFβ3 特异性抗体，与TGF-β1和TGF-β2没有React Species。
Product Picture	Sample:Ovary (Mouse)Lysate at 40 ug Primary: Anti-TGF-beta 3(SL20413R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 30'47kD Observed band size: 47kD Blank control（black line）:SH-SY5Y. Primary Antibody (green line): Rabbit Anti-TGF-beta 3 antibody (SL20413R) Dilution:1ug/Test; Secondary Antibody : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Negative control（white blue line）: PBS Isotype control（orange line）: Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃.The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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