Product Name	HAP1
Chinese Name	舞蹈症相关蛋白1抗体
Alias	Huntingtin Associated Protein 1; HAP 1; HAP 2; HAP2; HAP-1; Hap1; HAP1_HUMAN; HAPP; hHAP1; hHLP1; HIP 5; HIP5; HLP; HLP1; Huntingtin-associated protein 1; huntingtin-associated protein 2; Neuroan 1; Neuroan1.
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HAP1: 551-650/671
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Function: Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. Tissue Specificity: Predominantly expressed in brain. Selectively expressed in neurons. Similarity: Contains 1 HAP1 N-terminal domain. SWISS: P54257 Gene ID: 9001 Database links: Entrez Gene: 9001 Human Entrez Gene: 15114 Mouse Entrez Gene: 29430 Rat Omim: 600947 Human SwissProt: P54257 Human SwissProt: O35668 Mouse SwissProt: P54256 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HAP1) Polyclonal Antibody, Unconjugated (SL20303R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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