Product Name	Integrin Alpha V + Beta 1
Chinese Name	整合素αVβ1抗体
Alias	Integrin alpha 5 beta 1; fibronectin receptor alpha; ITGAV; CD51; DKFZp686A08142; MSK8; Msk 8; VNR; similar to Integrin alpha-V precursor; Vitronectin receptor subunit alpha; CD51 antigen; HGNC; Vitronectin receptor alpha polypeptide; Vitronectin receptor alpha polypeptide antigen CD51; VNRA; Integrin alpha 5 beta 1; VLA-5; Integrin alpha-5; ITGA5; ITA5_HUMAN; Integrin beta-1; ITGB1; ITB1_HUMAN;
literatures	Specific References  (7)     |     SL2016R has been referenced in 7 publications. [IF=7.182] Tingting Guo. et al. Lepidium meyenii Walpers polysaccharide and its cationic derivative re-educate tumor-associated macrophages for synergistic tumor immunotherapy. Carbohyd Polym. 2020 Dec;250:116904  WB ;  Mouse.   PubMed:33049880 [IF=6.638] Wong L et al. Substrate Stiffness Directs Diverging Vascular Fates. Acta Biomater. 2019 Jul 19. pii: S1742-7061(19)30519-7.  Inhibitor assay ;  Mouse.   PubMed:31326665 [IF=5.162] Liu S et al. Structural characterization of a novel polysaccharide from Panax notoginseng residue and its immunomodulatory activity on bone marrow dendritic cells. Int J Biol Macromol . 2020 Oct 15;161:797-809.  WB ;  Mouse.   PubMed:32553971 [IF=3.53] Hendesi H, Barbe MF, Safadi FF, Monroy MA, Popoff SN (2015) Integrin Mediated Adhesion of Osteoblasts to Connective Tissue Growth Factor (CTGF/CCN2) Induces Cytoskeleton Reorganization and Cell Differentiation. PLoS ONE 10(2): e0115325.  Mouse.   PubMed:25714841 [IF=2.924] Harper, Amy K.. et al. Binding of Intracellular Myeloperoxidase to αV/β1 Integrin Serves as a Mechanism of Survival in Epithelial Ovarian Cancer. REPROD SCI. 2022 Jul;:1-10  WB ;  Human.   PubMed:35799017 [IF=2.561] Chaudhary P et al. HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target β-catenin. Mol Cell Biochem. 2019 Mar;453(1-2):11-32.  ICF ;  Human.   PubMed:30136190 [IF=0] SHIRAKO H et al. Comparison of Anti-Inflammatory Analgesics for Mechanical Stress-induced Inflammation in a Human Synovial Sarcoma Cell Line. The Showa University Journal of Medical Sciences,2019 31(1), 51–62.  ICF ;  Human.   PubMed:doi:10.15369/sujms.31.51
Research Area	Cell biology  Signal transduction  The cell membrane受体  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1μg /test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	114kDa
Cellular localization	cytoplasmic Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic Mixed peptides 915-948/1048(human Integrin αV)+ 21-70/798(human Integrin β1)
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein se ems to enhance angiogenesis in Kaposi's sarcoma lesions. Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Subcellular Location: Membrane. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. SWISS: P06756 Gene ID: 3685 Database links: Entrez Gene: 3685 Human SwissProt: P06756 Human
Product Picture	Sample: Lane 1: A549 (Human) Cell Lysate at 30 ug Lane 2: U251 (Human) Cell Lysate at 30 ug Lane 3: Huvec (Human) Cell Lysate at 30 ug Lane 4: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 5: U2os (Human) Cell Lysate at 30 ug Lane 6: MCF-7 (Human) Cell Lysate at 30 ug Lane 7: Jurkat (Human) Cell Lysate at 30 ug Primary: Anti-Integrin Alpha V + Beta 1 (SL2016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 125 kD Observed band size: 125 kD Blank control (blue line): MCF7 (fixed with 70% methanol overnight at 4℃). Primary Antibody (green line): Rabbit Anti-Integrin Alpha V + Beta 1 antibody (SL2016R), Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE, Dilution: 1μg /test.

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