Product Name	LY6G6F
Chinese Name	lymphocyte抗原6重复位点蛋白G6F抗体
Alias	C6orf21; Chromosome 6 open reading frame 21; G6F; G6f protein [Precursor]; HCG43720, isoform CRA_c; LY66F_HUMAN; LY6G6D; Ly6g6f; Lymphocyte antigen 6 complex locus G6F; Lymphocyte antigen 6 complex locus protein G6f; Lymphocyte antigen 6 complex, locus G6D; NG32.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LY6G6F: 101-200/279
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	lymphocyte antigen 6 complex locus protein G6f is a single-pass type I membrane protein belonging to the immunoglobulin (Ig) superfamily. Located in the class III region of the major histocompatibility complex (MHC), the G6f gene lies in a cluster of genes encoding cell-surface proteins that play a role in the immune system and cellular recognition. G6f functions as a downstream effector of GRB2 and GRB7, and, in humans, it interacts with GRB2 and GRB7 through the phosphorylation of a tyrosine residue (Tyr 281) in the intracellular tail of G6f. This interaction is also mediated by the SH2 domain of GRB2 and possibly that of GRB7. G6f is a 297 amino acid protein, and it forms a disulfide-linked homodimer. Function: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. Subcellular Location: Cell membrane. Post-translational modifications: modificationsN-glycosylated. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q5SQ64 Gene ID: 259215 Database links: Entrez Gene: 259215 Human Omim: 611404 Human SwissProt: Q5SQ64 Human SwissProt: Q7Z5H2 Human Unigene: 591794 Human

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