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Product Name PCCB Chinese Name 丙酰辅酶A羧化酶β链抗体 Alias DKFZp451E113; PCCase subunit beta; pccB; PCCB_HUMAN; pccBC Complementation group; Propanoyl CoA:carbon dioxide ligase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; Propionyl CoA carboxylase beta chain, mitochondrial; propionyl Coenzyme A carboxylase, beta polypeptide; Propionyl-CoA carboxylase , beta subunit; Propionyl-CoA carboxylase beta chain, mitochondrial; R74805. Research Area Tumour Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 58kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCCB: 321-420/539 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Subunit:
Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.
Subcellular Location:
Mitochondrion matrix.
DISEASE:
Defects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.
Similarity:
Belongs to the AccD/PCCB family.
Contains 1 carboxyltransferase domain.
SWISS:
P05166
Gene ID:
5096
Database links:Entrez Gene: 5096 Human
Entrez Gene: 66904 Mouse
Omim: 232050 Human
SwissProt: P05166 Human
SwissProt: Q99MN9 Mouse
Unigene: 63788 Human
Unigene: 335385 Mouse
Unigene: 9732 Rat
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