Product Name	PBXIP1
Chinese Name	造血相互作用蛋白PBX抗体
Alias	4732463H20Rik; Hematopoietic PBX interacting protein; HPIP; MGC38361; Pre B cell leukemia homeobox interacting protein 1; RP11-307C12.2.
Research Area	Cell biology  Chromatin and nuclear signals  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PBXIP1: 631-731/731
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PBXIP1 is a regulator of pre-B-cell leukemia transcription factors (BPXs) function. It inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. PBXIP1 also tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. Function: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.3 Publications Manually curated information for which there is published experimental evidence. More… Manual assertion based on experiment ini Ref.1"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA." Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K. J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH PBX1; PBX2 AND PBX3, VARIANT ASP-357. Ref.6"Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP)." Abramovich C., Chavez E.A., Lansdorp P.M., Humphries R.K. Oncogene 21:6766-6771(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CHARACTERIZATION, SUBCELLULAR LOCATION. Ref.8"An inherent role of microtubule network in the action of nuclear receptor." Manavathi B., Acconcia F., Rayala S.K., Kumar R. Proc. Natl. Acad. Sci. U.S.A. 103:15981-15986(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ESR1, MUTAGENESIS OF 615-LEU--LEU-619. Subunit: Interacts with TEX11 (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3. Subcellular Location: Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus. Tissue Specificity: Expressed in early hematopoietic precursors. SWISS: Q96AQ6 Gene ID: 57326 Database links: Entrez Gene: 57326 Human Entrez Gene: 229534 Mouse Entrez Gene: 310644 Rat SwissProt: Q96AQ6 Human SwissProt: Q3TVI8 Mouse SwissProt: A2VD12 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PBXIP1) Polyclonal Antibody, Unconjugated (SL19901R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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