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Product Name RGS18 Chinese Name G protein signal转导调节因子18抗体 Alias Regulator of G protein signalling 13; Regulator of G Protein Signalling 18; Regulator of G-protein signaling 18; RGS 18; RGS13; RGS18; RGS18_HUMAN. Research Area Cell biology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RGS18: 1-100/255 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.
Similarity:
Contains 1 RGS domain.
SWISS:
Q9NS28
Gene ID:
64407
Database links:Entrez Gene: 64407 Human
Entrez Gene: 64214 Mouse
Omim: 607192 Human
SwissProt: Q9NS28 Human
SwissProt: Q99PG4 Mouse
Unigene: 440890 Human
Unigene: 253927 Mouse
Unigene: 202353 Rat
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