Product Name	SLC39A4
Chinese Name	溶质载体家族蛋白39成员A4抗体
Alias	1600025H15Rik; Acrodermatitis enteropathica zinc deficiency type; Activated in W/Wv mouse stomach 2; AEZ; AU041686; AWMS2; FLJ20327; MGC156705; MGC74741; S39A4_HUMAN; Slc39a4; Solute carrier family 39 member 4; Ssolute carrier family 39 zinc transporter member 4; Zinc transporter ZIP4; ZIP-4; ZIP4; Zrt and Irt like protein 4; Zrt- and Irt-like protein 4.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC39A4: 281-380/647
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. Subcellular Location: Cell membrane. Recycling endosome membrane. Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. Tissue Specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. DISEASE: Acrodermatitis enteropathica, zinc-deficiency type (AEZ) Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. SWISS: Q6P5W5 Gene ID: 55630 Database links: Entrez Gene: 55630 Human Entrez Gene: 72027 Mouse Omim: 607059 Human SwissProt: Q6P5W5 Human SwissProt: Q78IQ7 Mouse Unigene: 521934 Human Unigene: 276829 Mouse
Product Picture	Sample: MCF-7 (human)Cell Lysate at 40 ug Primary: Anti- SLC39A4 (SL19832R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size:66kD Observed band size: 71 kD Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC39A4) Polyclonal Antibody, Unconjugated (SL19832R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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